Mikhail G. Shapiro
Assistant: Irina Meininger
The Shapiro group develops molecular technologies for noninvasive imaging and control of cellular function, and uses these technologies to study basic biology and create cellular diagnostics and therapeutics.
Many important biological processes occur deep inside living organisms. Their study requires technologies to image and manipulate cellular and molecular function non-invasively. To develop such technologies, we pursue fundamental advances at the interface of molecular and cellular engineering with various forms of energy: acoustic, magnetic, mechanical, thermal and chemical. Our work takes advantage of naturally evolved biological structures with unique physical properties, which we use as starting points for engineering.
Our key biophysical methods include ultrasound and magnetic resonance , and our primary biological interests are in neuroscience, cancer, microbiology and immunology.
Publications
- Nayak, Rohit;Duan, Mengtong et al. (2024) Harmonic imaging for nonlinear detection of acoustic biomoleculesAPL Bioengineering
- Han, Hong;Ma, Xiaotian et al. (2024) Imaging-guided bioresorbable acoustic hydrogel microrobotsScience Robotics
- Sharma, Saransh;Melton, Hayward et al. (2024) A 14.8- μ W Power and < 10 μ T ᵣₘₛ Noise 3-D AC Magnetic Sensor in CMOS for Biomedical ApplicationsIEEE Journal of Solid-State Circuits
- Hurt, Robert C.;Jin, Zhiyang et al. (2024) Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic ScreeningACS Synthetic Biology
- Duan, Mengtong;Dev, Ishaan et al. (2024) SEMPER: Stoichiometric expression of mRNA polycistrons by eukaryotic ribosomes for compact, ratio-tunable multi-gene expressionCell Systems
- Li, Hongyi R.;Harb, Manwal et al. (2024) Engineering viral vectors for acoustically targeted gene deliveryNature Communications
- Hou, Jason F.;Nayeem, Md Osman Goni et al. (2024) An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activationNature Communications
- Rabut, Claire;Norman, Sumner L. et al. (2024) Functional ultrasound imaging of human brain activity through an acoustically transparent cranial windowScience Translational Medicine
- Schrunk, Erik;Dutka, Przemysław et al. (2024) Bioorthogonal Labeling Enables In Situ Fluorescence Imaging of Expressed Gas Vesicle NanostructuresBioconjugate Chemistry
- Ling, Bill;Gungoren, Bilge et al. (2024) Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and TherapyAdvanced Materials
2022-23
Instructors: Kornfield (a), Shapiro (b), Manthiram (c)
Instructor: Shapiro
2019-20
Instructors: Kornfield, Shapiro, Flagan