skip to main content

Cornelis Wiersma Visiting Professor of Neurobiology Lecture

Thursday, May 21, 2015
4:00pm to 5:00pm
Add to Cal
Kerckhoff 119
The Serendipitous Path of Discovery: From Protein Folding to Cognition
Peter Walter, University of California, San Francisco,

A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB proved to be a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.

For more information, please contact Linda Scott by phone at x4389 or by email at scottl@caltech.edu.