Cornelis Wiersma Visiting Professor of Neurobiology Lecture
Kerckhoff 119
The Serendipitous Path of Discovery: From Protein Folding to Cognition
Peter Walter,
University of California, San Francisco,
A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB proved to be a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.
For more information, please contact Linda Scott by phone at x4389 or by email at scottl@caltech.edu.
Event Series
General Biology Seminar Series