Research Summary
Systems biology, signaling pathways, robustness, biomaterial.
Profile
We are curious about how biological systems are built. We want to understand the engineering principles and the molecular mechanisms of how things are built and how things function. In the lab, we study multiple scales of biological organisation, from small protein circuits, signaling pathways, developmental programs, to organisms. We enjoy using various tools, such as paper-and-pencil mathematical modeling, computer simulation, biochemistry, single-cell imaging, histology, molecular biology, and lately, some cutting, pasting, and grinding experiments in embryos.
Our current research areas are:
Please see our lab website for more detailed information.
Publications
- Sierra, Noemie;Olsman, Noah et al. (2024) A novel approach to comparative RNA-Seq does not support a conserved set of orthologs underlying animal regenerationGenome Biology and Evolution
- Li, Yutian;Sarma, Anish A. et al. (2023) Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'eLife
- Ohdera, Aki H.;Darymple, Justin et al. (2022) Symbiosis-driven development in an early branching metazoan
- Abrams, Michael J.;Tan, Fayth Hui et al. (2021) A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and miceeLife
- Sierra, Noemie;Olsman, Noah et al. (2021) A novel approach to comparative RNA-Seq does not support a conserved set of genes underlying animal regeneration
- Olsman, Noah;Goentoro, Lea (2018) There's (still) plenty of room at the bottomCurrent Opinion in Biotechnology
- Nunns, Harry;Goentoro, Lea (2018) Signaling pathways as linear transmitterseLife
- Kim, Kibeom;Goentoro, Lea (2018) Choosing the right input in cell signalingScience
- Nath, Ravi D.;Bedbrook, Claire N. et al. (2017) The Jellyfish Cassiopea Exhibits a Sleep-like StateCurrent Biology
- Kim, Kibeom;Cho, Jaehyoung et al. (2017) Two-Element Transcriptional Regulation in the Canonical Wnt PathwayCurrent Biology