Research Summary
Mechanisms of large non-coding RNA mediated regulation of gene expression and cell state
Profile
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Our lab aims to understand the mechanisms by which lncRNAs act to control cellular functions. Specifically, we aim to understand how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to genomic DNA targets, and shaping three-dimensional (3D) nuclear organization.
Publications
- Sakai, Alexandra;Singh, Gagandeep et al. (2024) Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNAMoleclar Therapy - Nucleic Acids
- Perez, Andrew A.;Goronzy, Isabel N. et al. (2024) ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elementsNature Genetics
- Kitchen, Sheila A.;Naragon, Thomas H. et al. (2024) The genomic and cellular basis of biosynthetic innovation in rove beetlesCell
- Bhat, Prashant;Chow, Amy et al. (2024) Genome organization around nuclear speckles drives mRNA splicing efficiencyNature
- Guo, Jimmy K.;Blanco, Mario R. et al. (2024) Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivoMolecular Cell
- Wolin, Erica;Guo, Jimmy K. et al. (2023) SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress
- Mattick, John S.;Amaral, Paulo P. et al. (2023) Long non-coding RNAs: definitions, functions, challenges and recommendationsNature Reviews Molecular Cell Biology
- Bhat, Prashant;Chow, Amy et al. (2023) 3D genome organization around nuclear speckles drives mRNA splicing efficiency
- Goronzy, Isabel N.;Quinodoz, Sofia A. et al. (2022) Simultaneous mapping of 3D structure and nascent RNAs argues against nuclear compartments that preclude transcriptionCell Reports
- Guo, Jimmy K.;Guttman, Mitchell (2022) Regulatory non-coding RNAs: everything is possible, but what is important?Nature Methods