Research Summary
Advancing biomedical and cancer research.
Profile
Dr. Chou is interested in understanding the mechanisms of disease causing mutations of p97/VCP ATPase, a key player in cell proteasome and autophagy function, and has used p97 inhibitors as tools to develop pathway-specific inhibitors. Her main research focus is on discovering underlying mechanisms that may lead to new therapeutic targets for cancer and rare disease.
Publications
- Feng, Shu;Xie, Na et al. (2024) Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteinsNature Metabolism
- Tan, Chieh-Hsiang;Wang, Ting-Yu et al. (2024) Single-tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organellesProceedings of the National Academy of Sciences
- Pang, Marion;Jones, Jeff J. et al. (2024) Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent SamplesJournal of Proteome Research
- Lo, Yu-Li;Li, Ching-Yao et al. (2024) Exploring in vivo combinatorial chemo-immunotherapy: Addressing p97 suppression and immune reinvigoration in pancreatic cancer with tumor microenvironment-responsive nanoformulationBiomedicine & Pharmacotherapy
- Wallach, Izhar;Bernard, Denzil et al. (2024) AI is a viable alternative to high throughput screening: a 318-target studyScientific Reports
- Li, Ching-Yao;Chou, Tsui-Fen et al. (2024) An innovative nanoformulation utilizing tumor microenvironment-responsive PEG-polyglutamic coating and dynamic charge adjustment for specific targeting of ER stress inducer, microRNA, and immunoadjuvant in pancreatic cancer: In vitro investigationsInternational Journal of Biological Macromolecules
- Mah-Som, Annelise Y.;Daw, Jil et al. (2023) An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCPAmerican Journal of Human Genetics
- Godneeva, Baira;Fejes Toth, Katalin et al. (2023) Impact of Germline Depletion of Bonus on Chromatin State in Drosophila OvariesCells
- Zhang, Shu;Xie, Na et al. (2023) The Interferon-inducible NAMPT acts as a protein phosphoribosylase to restrict viral infection
- Mohanty, Atish;Nam, Arin et al. (2023) Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancerScience Advances